Toleransen for høye doser kan avta raskt dersom man slutter med opioider eller har en pause i bruk. I slike tilfeller er gentleman spesielt utsatt for overdoser dersom person inntar samme dose som tidligere.Fra gammel tid har man anvendt udtræk fra opiumsvalmuen i smertebehandling og disse midler er baseret på naturlige opioider eller de er kuns
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